By Randy J. Horwitz MD, PhD, Robert F. Lemanske Jr. MD (auth.), Phil Lieberman MD, John A. Anderson MD (eds.)
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Extra resources for Allergic Diseases: Diagnosis and Treatment
Williams PB, Dolen WK, Koepke JW, Selner JC. Immunoassay of specific IgE: use of a single point calibration curve in the modified radioallergosorbent test. Ann Allergy 1992; 69: 48-52. 4 Environmental Allergens Scott H Sicherer, MD and Peyton A. Eggleston, MD CONTENTS INTRODUCTION OUTDOOR ALLERGENS INDOOR ALLERGENS ACKNOWLEDGMENTS SUGGESTED READING INTRODUCTION Allergens are small-mol-wt proteins capable of inducing IgE antibody and triggering an allergic response. In our outdoor and indoor milieu, these allergenic proteins (along with a larger number of nonallergenic proteins) are carried on vectors, such as pollen grains or house dust particles, which may become airborne.
There are also the advantages of the patient being able to see the immediate allergic reaction on his or her own skin and the immediate availability of results. In comparison, in vitro tests offer the ability to test patients whose skin is not normally reactive either because of skin disease or because of interfering drugs. It may also be more convenient for both the patient and the physician to send blood samples to reference laboratories for testing, rather than for the patient to travel to another location for the testing.
In order for these particles to be clinically relevant as vectors for allergens, they must reach a high airborne concentration. The level of exposure to these particles is determined by the vicinity of the flora to the patient, the density of production of the pollen or spores by its source, the seasonal and diurnal timing of pollen or spore release, weather conditions, and the aerodynamic characteristics of the vector carrying the allergenic proteins. Flora that are present in great numbers and produce large pollen or spore burdens tend From: Allergic Diseases: Diagnosis and Treatment Edited by P.