By Simon McGinnes (auth.), Pericles Loucopoulos (eds.)
The transforming into call for for info platforms of ever-increasing measurement, scope, and complexity has highlighted the advantages that could be collected from ways which realize the interrelationships among various technological strands within the box of knowledge structures. standard examples of those components comprise: process improvement equipment, CASE, requisites engineering, database layout, and re-use. The CAiSE sequence of meetings presents the discussion board for the trade of effects and concepts inside those various technological spheres from a unmarried point of view, specifically that of data platforms improvement and administration. The 1992 convention, the fourth within the sequence, keeps this practice. This quantity collects the papers authorised for the convention, with authors from sixteen nations masking a variety of themes together with: object-oriented research and layout tools, the advance procedure and product help, specifications engineering, re-use, layout methods, and deductive approaches.
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Additional info for Advanced Information Systems Engineering: 4th International Conference CAiSE '92 Manchester, UK, May 12–15, 1992 Proceedings
Mutations introduced to inﬂuence one of those factors should have an impact on the pH-activity proﬁle of the enzyme. It is thought that the introduction of a negative charge in the surrounding of a titratable group produces an upward shift of the pKa value of a proton donor while the introduction of a positive charge should shift its pKa value downwards. Even this rather simple model is sometimes contradicted by the experiment. Wind et al. (40) inserted an additional positive or negative charge in the active site of cyclodextrin glycosyl transferase.
21. 22. 23. 24. 25. 26. 27. 28. 29. Henrissat et al. Advances in Carbohydrate Bioengineering. Cambridge: The Royal Society of Chemistry, 1999, pp 3–12. JA Campbell, GJ Davies, V Bulone, B Henrissat. A classiﬁcation of nucleotidediphospho-sugar glycosyltransferases based on amino acid sequence similarities. Biochem J 326:929–939, 1997. B Henrissat, A Bairoch. Updating the sequence-based classiﬁcation of glycosyl hydrolases. Biochem J 316:695–696, 1996. B Henrissat, PM Coutinho, GJ Davies. A census of carbohydrate-active enzymes in the genome of Arabidopsis thaliana.
Each family is annotated with information regarding all the enzyme activities that have been characterized and with the known catalytic and structural features. This summary is followed by a list of proteins and open reading frames (ORFs) belonging to the family with links to sequence and structural information available in public databases. Links to complementary relevant resources available on the Internet are also provided. An example is shown in Fig. 2. Because information on the repertoire of carbohydrate-active enzymes present in a given organism can provide interesting insights on its carbohydrate metabolism (16), a new feature was recently added where the user can access CAZy via organism (for organisms whose genome has been completely sequenced; see, example in Fig.